Interesting article from Pediatrics this past March looking at the epidemiology of sepsis in newborns.
The investigators conducted a retrospective review of over 160,000 full term infants that had a blood culture drawn. Only 2% were positive (93/4255), with 247 positive cultures being due to contaminants. The incidence rate in this study was 0.57 per 1000 live births.
Pathogen #1 was E coli (56%), and 98% of these infections were UTIs. GBS was second, and S aureus was third. Listeria and meningococcemia were left out in the cold (no cases of either).
Does this change your practice?
How would you alter your discussion with families about fever in the neonate after reading this study?
Are there any limitations to the methodology that are noteworthy?